Antiedematogenic activity of Petiveria alliacea L. in bothropic poisoning

The biodiversity of the Brazilian biomes inspires interest in research about biological activities molecules present flora. In this line, Petiveria alliacea a common plant species savanna Tocantins, reported treatment for snakebites, was studied to analyze phytochemical profile and evaluate activity on edema caused by Bothrops moojeni snake venom. A qualitative prospection gas chromatography associated with mass spectrometry performed. Subsequently, it evaluated whether extract triggered acute toxicity Swiss mice (doses 300 2,000 mg/kg), no toxic effects were observed. Then, antiedematogenic performed when administered orally simulated envenomation B. presence bioactive polyphenolics, flavonoids, tannins, coumarins, terpene, alkaloids saponins compounds shown. No observed, test showed evident activity. It is understood that inhibition induced venom obtained reducing pathways inflammatory cascade. Therefore, traditional effect has scientific basis, same way, its constituents qualified Key words: alliacea, moojeni, edema, inflammation, snakebite.